The Belgian Health Care Knowledge Centre (KCE) is an independent federal research institute in Belgium that provides multidisciplinary scientific advice to relevant persons and authorities on topics related to health care.

More specifically, the KCE carries out research on the organisation and financing of the health system (health services research), assesses health technologies and drugs (health technology assessment), establishes guidelines for clinical practice and updates them according to the latest scientific evidence (good clinical practices), and establishes validated methods for research in the field of health care and public health. Aside from producing scientific reports on these topics, the KCE also maintains a clinical research programme in which it selects and funds non-commercial clinical trials.

Lastly, the KCE critically reviews, analyses and summarizes publications from foreign research institutes and peer reviewed journals that could be of interest to Belgian clinicians and authorities.